A co-localization statistic is to identify individual (tissue/cell type specific) regulatory regions that are under sequence constraint. We employ a sliding-window type approach with window size 1 Kb, and 500 bps overlap, and for each such window we report a co-localization local fdr value. The UCSC Genome Browser Track Hub is provided to view the co-localized regulatory segments in the human genome assembly hg19 for 127 Roadmap cell types. There is an online spreadsheet with information about the 127 Roadmap cell types. The track displays co-localized regions which have local fdr < 0.3 in black segments.
Danqing Xu, Chen Wang, Krzysztof Kiryluk, Joseph D. Buxbaum, Iuliana Ionita-Laza, "Co-localization between sequence constraint and epigenomic information improves interpretation of whole genome sequencing data". Submitted.
The raw data in the bigWig format for the tracks are available here
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